The ZF21 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Miscellaneous, and ZFYVE21. This antibody recognizes Human, Mouse, and Rat antigen. The ZF21 Antibody has been validated for the following applications: ELISA, Immunofluorescence, and Western Blot.
Description
ZF21 Antibody: ZF21 was initially identified as protein that could bind to the cytoplasmic tail of MT1-MMP (Membrane-type 1 matrix metalloproteinase), a potent invasion-promoting protease. ZF21 is a member of a protein family characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain and regulates focal adhesions (FAs) and cell movement. Knockdown of ZF21 expression resulted in a delay of FA disassembly following induction of synchronous disassembly of FAs by nocodazole treatment, suggesting that ZF21 is involved in FA disassembly. ZF21 contains a noncanonical pleckstrin homology domain that is a possible therapeutic target to treat metastatic cancer